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Longevity startup Longevica plans to launch supplements based on long-term research
A biotech company that has spent 11 years researching supplements to increase human longevity plans to launch its supplements later this year. Longevica says it has attracted a total of $13 million from investors, including Alexander Chikunov, a longevity investor, who is also president of the company.
Longevica says it created a biotechnology platform for longevity after researching the life-span of laboratory mice. It now aims to produce medicines, dietary supplements and food products.
The longevity space is a growing sector for tech startups. Google backed the launch of Calico in the space. Late last year Humanity Inc. raised $2.5 million in a round led by Boston fund One Way Ventures for its longevity company that will leverage AI to maximize people’s health span.
Longevica’s CEO Aynar Abdrakhmanov, backing up his company’s aim to tap the desire for people to live longer, said: “According to the WHO, by 2050, 2 billion people will be 60+ years old. By 2026, the sales of services and products for this audience will be around $27 trillion… By comparison, it was only $17 trillion in 2019.”
According to CB Insights, life-extension startups raised a record total of $800 million in 2018 alone. And there are some high-profile investors in the space.
PayPal co-founder Peter Thiel invested in Unity Biotechnology, which is developing drugs to treat diseases that accompany aging. And Ethereum founder Vitalik Buterin invested $2.4 million worth of Ether into the nonprofit SENS Research foundation, where famed longevity research Aubrey de Grey is chief science officer, to develop rejuvenation biotechnologies.
Longevica is basing its platform on the work of scientist Alexey Ryazanov, who holds 10 U.S. patents in the space, and is a longtime researcher into the regulation of protein biosynthesis cells.
Chikunov said: “I gathered scientists known in this field to discuss their approaches to the problem. Then Alexey Ryazanov proposed the innovative idea of large-scale screening of all known pharmacological substances on long-lived mice in order to find those that prolong life.”
Under the leadership of Ryazanov, Longevica says it used 20,000 long-lived female mice and 1,033 drugs representing compounds from 62 pharmacological classes to find five substances that statistically significantly increased longevity by 16-22%: Inulin, Pentetic Acid, Clofibrate, Proscillaridin A, D-Valine.
From this work, they formed a view about the elimination of certain heavy metals from the body and improved the body’s ability to remove toxins.
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Just one week left to save $100 on TC Early Stage 2021: Marketing & Fundraising
Don’t let procrastination slow your roll. Yeah, we’re looking at you, early-stage founders. At TechCrunch, we love to reward action with savings. Want to save a cool $100? Buy your Early Stage 2021: Marketing & Fundraising pass before April 30, at 11:59 p.m. (PT), and you’ll keep a cool $100 in your pocket.
Take action, reap savings and get ready to join your community of early-inning startup founders for a two-day bootcamp (July 8-9) dedicated to helping you build a firm foundation for entrepreneurial success. We’re talking a day packed with highly interactive presentations, breakout sessions and plenty of time for Q&As with top-tier industry leaders and experts — plus a thrilling day-long pitch competition.
Part one of TC Early Stage 2021, which took place in April, featured folks like entrepreneur and VC Melissa Bradley, who delivered advice on nailing a virtual pitch meeting; Alexa von Tobel lead a discussion on finance for founders; and Fuel Capital’s Leah Solivan revealed 10 things not to do when you start a company.
Here’s just one example of the quality topics and guidance you can expect at TC Early Stage 2021 in July.
Plenty of founders struggle to find, or even define, product-market fit. And let’s face it, without the proper product-market fit, you basically have two chances of raising a unicorn: slim and fat. That’s why you won’t want to miss out on what Superhuman founder, CEO and product-market fit master Rahul Vohra has to say on the subject. Bring your questions and take advantage of his invaluable advice.
Pro Tip: We’re building our July agenda and announcing new speakers every week (like Mike Duboe and Sarah Kunst) — stay tuned!
Wondering whether attending TC Early Stage 2021: Marketing & Fundraising is worth your time and money? Here’s what two founders shared about their experience at last year’s event.
Early Stage 2020 provided a rich, bootcamp experience with premier founders, VCs and startup community experts. If you’re beginning to build a startup, it’s an efficient way to advance your knowledge across key startup topics. — Katia Paramonova, founder and CEO of Centrly.
Sequoia Capital’s session, Start with Your Customer, looked at the benefits of storytelling and creating customer personas. I took the idea to my team and we identified seven different user types for our product, and we’ve implemented storytelling to help onboard new customers. That one session alone has transformed my business. — Chloe Leaaetoa, founder, Socicraft.
TC Early Stage 2021: Marketing & Fundraising takes place on July 8-9, and you have just one week left to save $100 on the price of admission. Kick procrastination to the curb and keep more money in your wallet. Buy your TC Early Stage 2021 pass before April 30, at 11:59 p.m. (PT).
Is your company interested in sponsoring or exhibiting at Early Stage 2021 – Marketing & Fundraising? Contact our sponsorship sales team by filling out this form.
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Introvoke raises $2.7M to power online events that can be embedded anywhere
While there’s been plenty of attention and money lavished on virtual event platforms over the past year, Introvoke co-founder and CEO Oana Manolache predicted that we’re only at the beginning of a “third wave of digital transformation.”
In her framing, the first wave came at the beginning of the pandemic, when everyone was using video conferencing tools like Zoom for their virtual events. Next came conference platforms like Hopin (which has been raising money at a mind-boggling clip). But Manolache argued that even Hopin represents a “Band-Aid” that customers are hoping will tide them over until in-person events can resume — particularly when organizers have to point attendees to a third-party platform.
“One size does not fit all,” she said. “The Band-Aid solution that was only supposed to last for a couple months has had big benefits as companies grew their customer base and revenue targets. Now we’ve reached the third wave, as organizations want to bring solutions to their own universe and own their relationship with the audience.”
San Francisco-based Introvoke is a Techstars Accelerator graduate aiming to provide this third-wave solution. It’s announcing today that it has raised $2.7 million in funding led by Struck Capital, while Comcast, Social Leverage, Great Oaks, V1vc, Time CTO Bharat Krish and Resy co-founder Mike Montero also participated.
The startup offers components like virtual stages, chat rooms and networking hubs, all customizable and embeddable on a customer’s website. Manolache said Introvoke (the name comes from the idea of “thought-provoking introductions”) is designed for a hybrid future, which will take multiple forms: “Hybrid is going to mean virtual-only events, in-person only events and events that have in-person and virtual elements.”
Image Credits: Introvoke
Introvoke charges customers based on live event minutes, a model that it says is accessible to companies large and small. Its components can be embedded on websites built with WordPress, Squarespace, Wix, Splash and other platforms, but also on a customer’s internal intranet.
“We’ve been so impressed by the way customers are using the technology — conferences, career fairs, employee engagements,” Manolache said.
She added that as customers like Comcast, Wharton and Ritual Motion have used the platform in private preview mode, they’re beginning to break free of the in-person model. For example, Introvoke events can allow for attendees to chat with each other over weeks or months, not just a few days.
In a statement, Struck Capital founder and Managing Partner Adam B. Struck suggested that virtual events “will continue far beyond the COVID-19 pandemic.”
“Right now, virtual experiences, from conferences and concerts to company all-hands, are generally hosted on third party platforms, which creates a disjointed experience for the brand or organization hosting the event,” he continued. “Virtual enablement should be native to the website and platform of the enterprise itself, and it’s the role of technologists like the Introvoke team to make these experiences as seamless as any in-person event.”
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Hyundai invests in teleoperations startup Ottopia as part of $9M round
After spending much of his career in mission-critical environments, including the Israeli Air Force, Israeli Intelligence and leading development of a cybersecurity product at Microsoft, Amit Rosenzweig turned his attention to autonomous vehicles.
It was a technology that he soon recognized would need what every other mission-critical system requires: humans.
“I understood that there are so many edge cases that will not be solved purely by AI and machine learning, and there must be some kind of human-in-the-loop intervention,” Rosenzweig said in a recent interview. “You don’t have any mission-critical system on the planet — not nuclear power plants, not airplanes — without human supervision. A human must be in the loop or present in some way for autonomous mobility to exist, even in 10 or probably 20 years from now.”
That “human in the loop” conclusion led Rosenzweig to found teleoperations startup Ottopia in 2018. (His brother, Oren Rosenzweig is also in the autonomous vehicle business via the lidar company he co-founded, Innoviz.) Ottopia’s first product is a universal teleoperation platform that allows a human operator to monitor and control any type of vehicle from thousands of miles away. Ottopia’s software is combined with off-the-shelf hardware components like monitors and cameras to create a teleoperations center. The company’s software also includes assistive features, which provide “path” instructions to the AV without having to remotely control the vehicle.
Since launching, the small 25-person company has racked up investors and partners such as BMW, fixed-route AV startup May Mobility and Bestmile. Ottopia said Friday that it has raised $9 million from Hyundai Motor Group as well as Maven and IN Venture, the Israel-focused venture capital arm of Sumitomo Corporation. Existing investors MizMaa and Israeli firm NextGear also participated.
Hyundai and IN Venture also gained board seats. Woongjun Jang, who heads up Hyundai’s autonomous driving center, and IN Venture managing partner Eyal Rosner, are now on Ottopia’s board.
Ottopia has raised a total of $12 million to date, and Rosenzweig has already set his sights on a larger round to help fund the company’s growth.
For now, Rosenzweig is focused on doubling his workforce to 50 people by the end of the year and opening an office in the United States. Rosenzweig said the company is also expanding into other applications of its teleoperations software, including defense, mining and logistics. However, most of Ottopia’s resources will continue to be dedicated to automotive, and specifically the deployment of autonomous cars, trucks and shuttles.
“The motivation is really simple — it’s simple but it’s hard to do — and that’s to make affordable autonomous transportation closer to reality,” Rosenzweig said. “The problem of course is that when an AV does not have any kind of backup or any kind of safety net in the form of teleoperations and it gets stuck, passengers are going to get anxious, ‘what’s going on, why, why is this not moving’.”
The other problem, Rosenzweig noted, is that AVs need to be combined with an efficient transit service. That’s where he sees his newest partner, on-demand shuttle and transit software company Via, coming in.
Under the partnership, which was also announced this week, Via will offer autonomous vehicle fleets that combine its fleet management software with Ottopia’s teleoperations platform. Via is not developing its own self-driving software system. In November 2020, Via announced it had partnered with May Mobility to launch an autonomous vehicle platform that integrates on-demand shared rides, public transportation and transit options for passengers with accessibility needs.
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After going public, once-hot startups are riding a valuation roller coaster
To close out the week, a short meditation on value, or, more precisely, how assets are valued in today’s markets.
Do you recall the pre-direct-listing hype Coinbase enjoyed? After reporting its estimated first-quarter financial performance, interest in the domestic cryptocurrency trading giant ran red-hot.
When Coinbase set a $250 per-share direct listing reference price, it was broadly viewed as modest, if not downright low. Of course, a reference price is just that — a reference — so it wasn’t too big a deal. But it also wasn’t surprising that Coinbase shares traded as high as $429.54 on their first day, according to Yahoo Finance data.
Coinbase equity hasn’t topped $400 in any following day and is now under the $300 mark, with more declines set to arrive as trading commences. Its reference price looms, and suddenly a price that felt intensely conservative before Coinbase began to trade is starting to look nearly reasonable.
The Exchange explores startups, markets and money.
Read it every morning on Extra Crunch or get The Exchange newsletter every Saturday.
There have been other notable declines in value among some recently public, more technologically differentiated companies. The Exchange has watched with something akin to polite confusion as the value of Root, a neoinsurance company, fell to a third of its public-market highs after going public, even though it beat growth expectations in its most recent quarterly report.
We could toss UiPath into our trend of wildly meandering value. The company’s initial IPO price range targeted a price as low as $43 per share. Today it’s worth $76.75 per share in pre-market trading.
No one knows what anything is worth, again. This is the feeling I get while watching the markets work to determine how to value assets as diverse as startups crossing the private-public divide to the value of Bitcoin, which was supposed to keep going up. Until it suddenly reversed gear.
Frankly, we’re still dealing with new-enough models — or big-enough guesses about the future baked into business models — that it’s hard to really value the most uncertain (and therefore most exciting) companies, let alone cryptocurrencies. Let’s discuss.
Value?
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No one is talking about remote work from space
Hello and welcome back to Equity, TechCrunch’s venture capital-focused podcast, where we unpack the numbers behind the headlines.
First and foremost, Equity was nominated for a Webby for “Best Technology Podcast”!!! Drop everything and go Vote for Equity! We’d appreciate it. A lot. And even if we lose, well, we’ll keep doing our thing and making each other laugh.
Natasha and Danny and Alex and Chris got together to chat through the week’s biggest news. And like every other week in recent memory, it was a busy one. But we did our best to hit some M&A news, some unicorn news and some funding news from smaller startups.
Now, onto the show rundown; here’s what we discussed:
- The Discord-Microsoft deal is done, and Danny has a hot take. Namely, in his view, the deal was mostly banker chatter more than a real possibility. More chaff than wheat, in other words. Agree or not, we’re stoked for the Discord IPO in a few years (quarters?) time.
- Mastercard bought Erkata, and Danny was on hand to explain why we care about the deal. Sure, it was $825 million in value, but some venture data from Finledger helped explain just how much capital is flowing into similar companies. Let’s see how that math works out.
- Clearbanc rebranded itself into a fintech unicorn, providing services along with sweet, sweet capital.
- The UiPath IPO finally priced and started to trade. It had a good first day, and you can check out what we learned talking to its CFO here.
- Over in China, a country that we’ve not covered enough lately, Laiye raised $50 million more. Like UiPath it competes in the RPA world.
- Deel, for one, had a good 2020. It hit 20x growth in revenue last year, and recently raised at a $1.25 billion valuation.
- And then we closed with two seed rounds raised by recent Y Combinator grads: Here’s the Queenly round, and here’s the Albedo deal!
We’ll see you on Monday.
Equity drops every Monday at 7:00 a.m. PST, Wednesday, and Friday at 6:00 AM PST, so subscribe to us on Apple Podcasts, Overcast, Spotify and all the casts!
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The TechCrunch Germany Survey — Calling Hamburg, Munich, Cologne, Bielefeld, Frankfurt
TechCrunch is embarking on a major new project to survey European founders and investors in cities outside the larger European capitals.
Over the next few weeks, we will ask entrepreneurs in these cities to talk about their ecosystems, in their own words.
This is your chance to put Hamburg, Munich, Cologne, Bielefeld and Frankfurt on the TechCrunch Map!
If you are a tech startup founder or investor in these cities please fill out the survey form here.
We are particularly interested in hearing from women founders and investors.
This is the follow-up to the huge survey of investors we’ve done over the last six or more months, largely in capital cities.
These formed part of a broader series of surveys we’re doing regularly for Extra Crunch, our subscription service that unpacks key issues for startups and investors.
In the first wave of surveys, the cities we wrote about were largely capitals. You can see them listed here.
This time, we will be surveying founders and investors in Europe’s other cities to capture how European hubs are growing, from the perspective of the people on the ground.
We’d like to know how your city’s startup scene is evolving, how the tech sector is being impacted by COVID-19 and generally how your city will evolve.
We leave submissions mostly unedited and are generally looking for at least one or two paragraphs in answer to the questions.
So if you are a tech startup founder or investor in one of these cities please fill out our survey form here.
Thank you for participating. If you have questions you can email mike@techcrunch.com and/or reply on Twitter to @mikebutcher.
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To sell or not to sell: Lessons from a bootstrapped CEO
The clock begins ticking on a startup the day the doors open. Regardless of a young company’s struggles or success, sooner or later the question of when, how or whether to sell the enterprise presents itself. It’s possibly the biggest question an entrepreneur will face.
For founders who self-funded (bootstrapped) their startup, a boardroom full of additional factors come into play. Some are the same as for investor-funded firms, but many are unique.
Put happiness at the center of the decision, and let your intuition — the instincts that made you the person you are today — be your guide.
After 18 years of bootstrapping a BI software firm into a business that now serves 28,000 companies and three million users in 75 countries, here’s what I’ve learned about myself, my company, about entrepreneurship and about when to grab for that brass ring.
Profitable or bust
Starting a software company 7,900 miles southwest of Silicon Valley requires some forethought and not a small amount of crazy. When we opened, it didn’t occur to us that one could have an idea and then go knock on someone’s door and ask for money.
Bootstrapping forced us to be a bit more creative about how we would go about building our company. In the early days, it was a distraction to growth, because we were doing other revenue-generating activities like consulting, development work, whatever we could find to keep ourselves afloat while we built Yellowfin. It meant we couldn’t be 100% focused on our idea.
However, it also meant we had to generate income from our new company from Day One — something funded companies don’t have to do. We never got into the mindset that it was okay to burn lots of cash and then cross our fingers and hope that it worked.
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5 emerging use cases for productivity infrastructure in 2021
When the world flipped upside down last year, nearly every company in every industry was forced to implement a remote workforce in just a matter of days — they had to scramble to ensure employees had the right tools in place and customers felt little to no impact. While companies initially adopted solutions for employee safety, rapid response and short-term air cover, they are now shifting their focus to long-term, strategic investments that empower growth and streamline operations.
As a result, categories that make up productivity infrastructure — cloud communications services, API platforms, low-code development tools, business process automation and AI software development kits — grew exponentially in 2020. This growth was boosted by an increasing number of companies prioritizing tools that support communication, collaboration, transparency and a seamless end-to-end workflow.
Productivity infrastructure is on the rise and will continue to be front and center as companies evaluate what their future of work entails and how to maintain productivity, rapid software development and innovation with distributed teams.
According to McKinsey & Company, the pandemic accelerated the share of digitally enabled products by seven years, and “the digitization of customer and supply-chain interactions and of internal operations by three to four years.” As demand continues to grow, companies are taking advantage of the benefits productivity infrastructure brings to their organization both internally and externally, especially as many determine the future of their work.
Automate workflows and mitigate risk
Developers rely on platforms throughout the software development process to connect data, process it, increase their go-to-market velocity and stay ahead of the competition with new and existing products. They have enormous amounts of end-user data on hand, and productivity infrastructure can remove barriers to access, integrate and leverage this data to automate the workflow.
Access to rich interaction data combined with pre-trained ML models, automated workflows and configurable front-end components enables developers to drastically shorten development cycles. Through enhanced data protection and compliance, productivity infrastructure safeguards critical data and mitigates risk while reducing time to ROI.
As the post-pandemic workplace begins to take shape, how can productivity infrastructure support enterprises where they are now and where they need to go next?
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Fraud prevention platform Sift raises $50M at over $1B valuation, eyes acquisitions
With the increase of digital transacting over the past year, cybercriminals have been having a field day.
In 2020, complaints of suspected internet crime surged by 61%, to 791,790, according to the FBI’s 2020 Internet Crime Report. Those crimes — ranging from personal and corporate data breaches to credit card fraud, phishing and identity theft — cost victims more than $4.2 billion.
For companies like Sift — which aims to predict and prevent fraud online even more quickly than cybercriminals adopt new tactics — that increase in crime also led to an increase in business.
Last year, the San Francisco-based company assessed risk on more than $250 billion in transactions, double from what it did in 2019. The company has over several hundred customers, including Twitter, Airbnb, Twilio, DoorDash, Wayfair and McDonald’s, as well a global data network of 70 billion events per month.
To meet the surge in demand, Sift said today it has raised $50 million in a funding round that values the company at over $1 billion. Insight Partners led the financing, which included participation from Union Square Ventures and Stripes.
While the company would not reveal hard revenue figures, President and CEO Marc Olesen said that business has tripled since he joined the company in June 2018. Sift was founded out of Y Combinator in 2011, and has raised a total of $157 million over its lifetime.
The company’s “Digital Trust & Safety” platform aims to help merchants not only fight all types of internet fraud and abuse, but to also “reduce friction” for legitimate customers. There’s a fine line apparently between looking out for a merchant and upsetting a customer who is legitimately trying to conduct a transaction.
Sift uses machine learning and artificial intelligence to automatically surmise whether an attempted transaction or interaction with a business online is authentic or potentially problematic.
Image Credits: Sift
One of the things the company has discovered is that fraudsters are often not working alone.
“Fraud vectors are no longer siloed. They are highly innovative and often working in concert,” Olesen said. “We’ve uncovered a number of fraud rings.”
Olesen shared a couple of examples of how the company thwarted fraud incidents last year. One recently involved money laundering through donation sites where fraudsters tested stolen debit and credit cards through fake donation sites at guest checkout.
“By making small donations to themselves, they laundered that money and at the same tested the validity of the stolen cards so they could use it on another site with significantly higher purchases,” he said.
In another case, the company uncovered fraudsters using Telegram, a social media site, to make services available, such as food delivery, with stolen credentials.
The data that Sift has accumulated since its inception helps the company “act as the central nervous system for fraud teams.” Sift says that its models become more intelligent with every customer that it integrates.
Insight Partners Managing Director Jeff Lieberman, who is a Sift board member, said his firm initially invested in Sift in 2016 because even at that time, it was clear that online fraud was “rapidly growing.” It was growing not just in dollar amounts, he said, but in the number of methods cybercriminals used to steal from consumers and businesses.
“Sift has a novel approach to fighting fraud that combines massive data sets with machine learning, and it has a track record of proving its value for hundreds of online businesses,” he wrote via email.
When Olesen and the Sift team started the recent process of fundraising, Insight actually approached them before they started talking to outside investors “because both the product and business fundamentals are so strong, and the growth opportunity is massive,” Lieberman added.
“With more businesses heavily investing in online channels, nearly every one of them needs a solution that can intelligently weed out fraud while ensuring a seamless experience for the 99% of transactions or actions that are legitimate,” he wrote.
The company plans to use its new capital primarily to expand its product portfolio and to scale its product, engineering and sales teams.
Sift also recently tapped Eu-Gene Sung — who has worked in financial leadership roles at Integral Ad Science, BSE Global and McCann — to serve as its CFO.
As to whether or not that meant an IPO is in Sift’s future, Olesen said that Sung’s experience of taking companies through a growth phase such as what Sift is experiencing would be valuable. The company is also for the first time looking to potentially do some M&A.
“When we think about expanding our portfolio, it’s really a buy/build partner approach,” Olesen said.
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