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Engine Biosciences expands its digital drug discovery pipeline with $43M round

Drug discovery is a large and growing field, encompassing both ambitious startups and billion-dollar Big Pharma incumbents. Engine Biosciences is one of the former, a Singaporean outfit with an expert founding crew and a different approach to the business of finding new therapeutics, and it just raised $43 million to keep growing.

Digital drug discovery in general means large-scale analysis of biological data like genes, gene expression, protein structures, binding sites, things like that. Where it has hit a wall in the past is not on the digital side, where any number of likely molecules or processes can be generated, but on the next step, when those notions need to be tested in vitro. So a new crop of biotech companies have worked to integrate these aspects.

Engine does so with a pair of tools it has dubbed NetMAPPR and CombiGEM. NetMAPPR is a huge sort of search engine for genes and gene interactions, taking special note of “errors” that could provide a foothold for a molecule or treatment. CombiGEM is like a mass genetic testing process that can look into thousands of gene combinations and edits on diseased cells simultaneously, providing quick experimental confirmation of the targets and effects proposed by the digital side. The company is focused on anti-cancer drugs but is looking into other fields as they become viable.

Jeffrey Lu, Co-Founder and CEO, Engine Biosciences

Image Credits: Engine Biosciences

The focus on gene interactions sets their approach apart, said co-founder and CEO Jeffrey Lu.

“Gene interactions are relevant to all diseases, and in cancers, where we focus, a proven approach for effective precision medicines,” he explained. “For example, there are four approved drugs targeting the PARP enzyme in the context of mutation in the BRCA gene that is changing cancer treatment for millions of people. The fundamental principle of this precision medicine is based on understanding the gene interaction between BRCA and PARP.”

The company raised a $10 million seed in 2018 and has been doing its thing ever since — but it needs more money if it’s going to bring some of these things to market.

“We already have chemical compounds directed toward the novel biology we have uncovered,” said Lu. “These are effectively prototype drugs, which are showing anti-cancer effects in diseased cells. We need to refine and optimize these prototypes to a suitable candidate to enter the clinic for testing in humans.”

Right now they’re working with other companies to do the next step up from automated testing, which is to say animal testing, to clear the way for human trials.

The CombiGEM experiments — hundreds of thousands of them — produce a large amount of data as well, and they’re sharing and collaborating on that front with several medical centers throughout Asia. “We have built what we believe to be the largest data compendium related to gene interactions in the context of cancer disease relevance,” said Lu, adding that this is crucial to the success of the machine learning algorithms they employ to predict biological processes.

The $43 million round was led by Polaris Partners, with participation by newcomers Invus and a long list of existing investors. The money will go toward the requisite testing and paperwork involved in bringing a new drug to market based on promising leads.

“We have small molecule compounds for our lead cancer programs with data from in vitro (in cancer cells) experiments. We are refining the chemistry and expanding studies this year,” said Lu. “Next year, we anticipate having our first drug candidate enter the late preclinical phase of development and regulatory work for an IND (investigational new drug) filing with the FDA, and starting the clinical trials in 2023.”

It’s a long road to human trials, let alone widespread use, but that’s the risk any drug discovery startup takes. The carrot dangling in front of them is not just the possibility of a product that could generate billions in income, but perhaps save the lives of countless cancer patients awaiting novel therapies.

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Vise CEO Samir Vasavada and Sequoia’s Shaun Maguire break down the art of the pitch

In just a few short years, Vise has gone from launching on the Disrupt Battlefield stage to unicorn. Co-founders Samir Vasavada and Runik Mehrotra met Sequoia’s Shaun Maguire at an afterparty at the event, and Maguire ended up leading a seed and Series A round while Sequoia led the Series B. Last week, Vise raised its Series C of $65 million and was officially valued at $1 billion post-money.

A good pitch deck is short and simple, and covers the key points in less than 12 words a slide.

We sat down with Vasavada and Maguire to talk about the early fundraising process for Vise, specifically the seed round, and get a look at the startup’s first pitch deck. We discussed what Vasavada has learned about delivering a good fundraising pitch, and what stood out about the pitch and the product for Maguire.

Simplicity is key

Vasavada says he’s made dozens of pitch decks since starting Vise and that this early deck was not his best because it was trying to do too much.

“A good pitch deck is short and simple, and covers the key points in less than 12 words a slide,” said Vasavada, adding that many founders think they need to show investors every part of their business.

“The deck has to show that you’re solving an important problem, that you’ve got the path to an important solution, that there is a big market opportunity, and that your team is positioned to execute,” he said. “Those are the only four things that matter. Everything else can be discussed in the Q&A.”

The goal of a pitch meeting is not to get the “yes” instantly, and satisfy every curiosity, but rather to give the investor something to think about and a reason to want another conversation.

Vasavada explained to the audience that this early seed deck certainly went into too much detail and was too text-heavy. (You can check out the full deck below.)

Why will this product be successful right now?

Beyond the problem, solution, market and team, there is an additional X factor that makes a difference in pitching for fundraising.

Timing can make or break a startup. Incredible ideas, ones that have gone on to be some of the biggest businesses in the world, have fizzled out and died for being too early.

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Poparazzi hypes itself to the top of the App Store

If Instagram’s photo tagging feature was spun out into its own app, you’d have the viral sensation Poparazzi, now the No. 1 app on the App Store. The new social networking app, from the same folks behind TTYL and others, lets you create a social profile that only your friends can post photos to — in other words, making your friends your own “paparazzi.” To its credit, the new app has perfectly executed on a series of choices designed to fuel day-one growth — from its prelaunch TikTok hype cycle to drive App Store preorders to its postlaunch social buzz, including favorable tweets by its backers. But the app has also traded user privacy in some cases to amplify network effects in its bid for the Top Charts, which is a risky move in terms of its long-term staying power.

The company positions Poparazzi as a sort of anti-Instagram, rebelling against today’s social feeds filled with edited photos, too many selfies and “seemingly effortless perfection.” People’s real lives are made up of many unperfect moments that are worthy of being captured and shared, too, a company blog post explains.

This manifesto hits the right notes at the right time. User demand for less performative social media has been steadily growing for years — particularly as younger, Gen Z users wake up to the manipulations by tech giants. We’ve already seen a number of startups try to siphon users away from Instagram using similar rallying cries, including Minutiae, Vero, Dayflash, Oggl and, more recently, the once-buzzy Dispo and the under-the-radar Herd.

Even Facebook has woken up to consumer demand on this front, with its plan to roll out new features that allow Facebook and Instagram users to remove the Like counts from their posts and their feeds.

Poparazzi hasn’t necessarily innovated in terms of its core idea — after all, tagging users in photos has existed for years. In fact, it was one of the first viral effects introduced by Facebook in its earlier days.

Instead, Poparazzi hit the top of the charts by carefully executing on growth strategies that ensured a rocket ship-style launch.

@poparazziappcomment it! ##greenscreen ##poparazziapp ##positivity ##foryoupage♬ Milkshake – BBY Kodie

The company began gathering prelaunch buzz by driving demand via TikTok — a platform that’s already helped mint App Store hits like the mobile game High Heels. TikTok’s powers are still often underestimated, even though its potential to send apps up the Top Charts have successfully boosted downloads for a number of mobile businesses, including TikTok sister app CapCut and e-commerce app Shein, for example.

And Poparazzi didn’t just build demand on TikTok — it actually captured it by pointing users to its App Store preorders page via the link in its bio. By the time launch day rolled around, it had a gaggle of Gen Z users ready and willing to give Poparazzi a try.

The app launches with a clever onboarding screen that uses haptics to buzz and vibrate your phone while the intro video plays. This is unusual enough that users will talk and post about how cool it was — another potential means of generating organic growth through word-of-mouth.

After getting you riled up with excitement, Poparazzi eases you into its bigger data grab.

First, it signs up and authenticates users through a phone number. Despite Apple’s App Store policy, which requires it, there is no privacy-focused option to use “Sign In with Apple,” which allows users to protect their identity. That would have limited Poparazzi’s growth potential versus its phone number and address book access approach.

It then presents you with a screen where it asks for permission to access your Camera (an obvious necessity) and Contacts (wait, all of them?), and permission to send you Notifications. This is where things start to get more dicey. The app, like Clubhouse once did, demands a full address book upload. This is unnecessary in terms of an app’s usability, as there are plenty of other ways to add friends on social media — like by scanning each other’s QR code, typing in a username directly or performing a search.

But gaining access to someone’s full Contacts database lets Poparazzi skip having to build out features for the privacy-minded. It can simply match your stored phone numbers with those it has on file from user signups and create an instant friend graph.

As you complete each permission, Poparazzi rewards you with green checkmarks. In fact, even if you deny the permission being asked, the green check appears. This may confuse users as to whether they’ve accidently given the app access.

While you can “deny” the Address Book upload — a request met with a tsk tsk of a pop-up message — Poparazzi literally only works with friends, it warns you — you can’t avoid being found by other Poparazzi users who have your phone number stored in their phone.

When users sign up, the app matches their address book to the phone number it has on file and then — boom! — new users are instantly following the existing users. And if any other friends have signed up before you, they’ll be following you as soon as you log in the first time.

In other words, there’s no manual curation of a “friend graph” here. The expectation is that your address book is your friend graph, and Poparazzi is just duplicating it.

Of course, this isn’t always an accurate presentation of reality.

Many younger people, and particularly women, have the phone numbers of abusers, stalkers and exes stored in their phone’s Contacts. By doing so, they can leverage the phone’s built-in tools to block the unwanted calls and texts from that person. But because Poparazzi automatically matches people by phone number, abusers could gain immediate access to the user profiles of the people they’re trying to harass or hurt.

Sure, this is an edge case. But it’s a nontrivial one.

It’s a well-documented problem, too — and one that had plagued Clubhouse, which similarly required full address book uploads during its early growth phase. It’s a terrible strategy to become the norm, and one that does not appear to have created a lasting near-term lock-in for Clubhouse. It’s also not a new tactic. Mobile social network Path tried address book uploads nearly a decade ago and almost everyone at the time agreed this was not a good idea.

As carefully designed as Poparazzi is — (it’s even got a blue icon — a color that denotes trustworthiness!) — it’s likely the company intentionally chose the trade-off. It’s forgoing some aspects of user privacy and safety in favor of the network effects that come from having an instant friend graph.

The rest of the app then pushes you to grow that friend graph further and engage with other users. Your profile will remain bare unless you can convince someone to upload photos of you. A SnapKit integration lets you beg for photo tags over on Snapchat. And if you can’t get enough of your friends to tag you in photos, then you may find yourself drawn to the setting “Allow Pops from Everyone,” instead of just “People You Approve.”

There’s no world in which letting “everyone” upload photos to a social media profile doesn’t invite abuse at some point, but Poparazzi is clearly hedging its bets here. It likely knows it won’t have to deal with the fallout of these choices until further down the road — after it’s filled out its network with millions of disgruntled Instagram users, that is.

Dozens of other growth hacks are spread throughout the app, too, from multiple pushes to invite friends scattered throughout the app to a very Snapchatt-y “Top Poparazzi” section that will incentivize best friends to keep up their posting streaks.

It’s a clever bag of tricks. And though the app does not offer comments or followers counts, it isn’t being much of an “anti-Instagram” when it comes to chasing clout. The posts — which can turn into looping GIFs if you snap a few in a row — may be more “authentic” and unedited than those on Instagram; but Poparazzi users react to posts with a range of emojis and how many reactions a post receives is shown publicly.

For beta testers featured on the explore page, reactions can be in the hundreds or thousands — effectively establishing a bar for Pop influence.

Finally, users you follow have permission to post photos, but if you unfollow them — a sure sign that you no longer want them to be in your poparazzi squad — they can still post to your profile. As it turns out, your squad is managed under a separate setting under “Allow Pops From.” That could lead to trouble. At the very least, it would be nice to see the app asking users if they also want to remove the unfollowed account’s permission to post to your profile at the time of the unfollow.

Overall, the app can be fun — especially if you’re in the young, carefree demographic it caters to. Its friend-centric and ironically anti-glam stance is promising as well. But additional privacy controls and the ability to join the service in a way that offers far more granular control of your friend graph in order to boost anti-abuse protections would be welcome additions. 

TechCrunch tried to reach Poparazzi’s team to gain their perspective on the app’s design and growth strategy, but did not hear back. (We understand they’re heads down for the time being.) We understand, per SignalFire’s Josh Constine and our own confirmation, that Floodgate has invested in the startup, as has former TechCrunch co-editor Alexia Bonatsos’ Dream Machine and Weekend Fund.

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Zoom fatigue no more: Rewatch raises $20M to index, transcribe and store enterprise video content

We don’t hear as much these days about “Zoom fatigue” as we did in the first months after the COVID-19 pandemic kicked off last year, but what’s less clear is whether people became more tolerant of the medium, or if they found ways of coping with it better, or if they were hopeful that tools for coping would soon be around the corner.

Today, a startup that has come up with a solution to handling all that video is announcing some funding to grow, on the understanding that whatever people are doing with video today, there will be a lot more video to handle in the future, and they will need more than just a good internet connection, microphone and video camera to deal with it.

Rewatch, which has built a set of tools for organizations to create a “system of record” for their internal video archives — not just a place to “rewatch” all of their older live video calls, but to search and organise information arising from those calls — has closed a $20 million round of funding.

Along with this, Rewatch from today is opening up its platform from invite-only to general availability.

This latest round is a Series A and is being led by Andreessen Horowitz, with Semil Shah at Haystack and Kent Goldman at Upside Partners, as well as a number of individuals, also participating.

It comes on the heels of Rewatch announcing a $2 million seed round only in January of this year. But it’s had some buzz in the intervening months: Customers that have started using Rewatch include GitHub (where co-founders Connor Sears and Scott Goldman previously worked together), Brex, Envoy and The Athletic.

The issue that Rewatch is tackling is the fact that a lot more of our work communications are happening over video. But while video calling has been hailed as a great boost to productivity — you can work wherever you are now, as long as you have a video connection — in fact, it’s not.

Yes, we are talking to each other a lot, but we are also losing information from those calls because they’re not being tracked as well as they could be. And, by spending all of our time talking, many of us are working on other things less, or are confined into more rigid times when we can.

Rewatch has built a system that plugs into Zoom and Google Meet, two of the most-used video tools in the workplace, and automatically imports all of your office’s or team’s video chats into a system. This lets you browse libraries of video-based conversations or meetings to watch them on-demand, on your time. It also provides transcripts and search tools for finding information in those calls.

You can turn off the automatic imports, or further customize how meetings are filed or accessibility. Sears said that Rewatch can be used for any video created on any platform; for now those require manually importing the videos into the Rewatch system.

Sears also said that over time it will also be adding ways to automatically turn items from meetings into, say, work tickets to follow them up.

While there are a number of transcription services available on tap these days, as well as any number of cloud-based storage providers where you can keep video archives, what is notable about Rewatch is that it has identified the pain point of managing and indexing those archives and keeping them in a single place for many to use.

In this way, Rewatch is highlighting and addressing what I think of as the crux of the productivity paradox.

Essentially, it is this: The tech industry has given us a lot of tools to help us work better, but actually, the work required to use those tools can outweigh the utility of the tools themselves.

(And I have to admit, this is one of the reasons I’ve grown to dislike Slack. Yes, we all get to communicate on it, and it’s great to have something to connect all of us, but it just takes up so much damn time to read through everything and figure out what’s useful and what is just watercooler chat.)

“We go to where companies already are, and we automate, pull in video so that you don’t have to think about it,” Sears said. “The effort around a lot of this takes a lot of diligence to make sure people are recording and transcribing and distributing and removing. We are making this seamless and effortless.”

It sometimes feels like we are on the cusp, technologically, of leaning on tools by way of AI and other innovations that might finally cross that chasm and give us actual productivity out of our productivity apps.

In another example of how this is playing out, Dooly, which raised funding last week, is looking to do the same in the world of sales software (automatically populating various sales software with data from your phone, video and text chats, and other sources).

Similarly, we’re starting to see an interesting wave of companies emerge that are looking for better ways to manage and tap into all that video content that we now have swimming around us.

AnyClip, which announced funding yesterday, is also applying better analytics and search to internal company video libraries, but also has its sights on a wider opportunity: organizing any video trove. That points, too, to the bigger opportunity for Rewatch.

For now, though, enterprises and businesses are an opportunity enough.

“As investors we get excited about founders first and foremost, and Connor and Scott immediately impressed us with their experience, clear articulation of the problem, and their vision for how Rewatch could be the end-all solution for video and knowledge management in an organization,” noted David Ulevitch, a general partner at Andreessen Horowitz, in a blog post. “They both worked at GitHub in senior roles from the early days, as a Senior Director of Product Design and a Principal Engineer, respectively, and have first-hand experience scaling a product. Since founding Rewatch in early 2020, they have very quickly built a great product, sold it to large-scale customers, and hired top-tier talent, demonstrating rapid founder and company velocity that is key to building an enduring company.”

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Uptycs secures $50M Series C as security platform continues to expand

Uptycs, a Boston-area startup that uses data to help understand and prevent security attacks, announced a $50 million Series C today, 11 months after announcing a $30 million Series B. Norwest Venture Partners led the round with participation from Sapphire Ventures and ServiceNow Ventures.

Company co-founder and CEO Ganesh Pai says that he was still well capitalized from last year’s investment, and wasn’t actually looking to raise funds, but the investors came looking for him and he saw a way to speed up some aspects of the company’s roadmap.

“It was one of those things where the round came in primarily as a function of execution and success to date, and we decided to capitalize on that because we know the partners and raised the capital so that we could use it meaningfully for a couple of different things, primarily sales and marketing acceleration,” Pai said.

He said that part of the reason for the company’s success over the last year was that the pandemic generated more customer interest as people moved to work from home, the SolarWinds hack happened and companies were moving to the cloud faster. “We provided a solution which was telemetric powered and very insightful when it came to solving their security problems and that’s what led to triple digit growth over the last year,” he said.

But Pai says that the company has not been sitting still in terms of the platform. While last year, he described it primarily as a forensic security data solution, helping customers figure out what happened after a security issue has happened, he says that the company has begun expanding on that vision to include all four main areas of security, including being proactive, reactive, predictive and protective.

The company started primarily in being reactive by figuring what happened in the past, but has begun to expand into these other areas over the last year, and the plan is to continue to build out that functionality.

“In the context of SolarWinds, what everyone is trying to figure out is how soon into the supply chain can you figure out what could be potentially wrong by looking at indications of behavior or indications of compromise, and our ability to ingest telemetry from a diverse set of sources, not as a bolt-on solution, but something which is built from the ground up, resonated really well,” Pai explained.

The company had 65 employees when we spoke last year for the Series B. Today, Pai says that number is approaching 140 and he is adding new people every week, with a goal to get to around 200 people by the end of the year. He says as the company grows, he keeps diversity top of mind.

“As we grow and as we raise capital diversity has been something which has been a high priority and very critical for us,” he said. In fact, he reports that more than 50% of his employees come from under-represented groups whether it’s Latinx, Black or Asian heritage.

Pai says that one of the reasons he has been able to build a diverse workforce is his commitment to a remote workplace, which means he can hire from anywhere, something he will continue to do even after the pandemic ends.

 

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Emotion-detection software startup Affectiva acquired for $73.5M

Smart Eye, the publicly traded Swedish company that supplies driver monitoring systems for a dozen automakers, has acquired emotion-detection software startup Affectiva for $73.5 million in a cash-and-stock deal.

Affectiva, which spun out of the MIT Media Lab in 2009, has developed software that can detect and understand human emotion, which Smart Eye is keen to combine with its own AI-based eye-tracking technology. The companies’ founders see an opportunity to expand beyond driver monitoring systems — tech that is often used in conjunction with advanced driver assistance systems to track and measure awareness — and into the rest of the vehicle. Together, the technology could help them break into the emerging “interior sensing” market, which can be used to monitor the entire cabin of a vehicle and deliver services in response to the occupant’s emotional state.

Under the terms of the deal, $67.5 million will be paid with 2,354,668 new Smart Eye shares, of which 2,015,626 are to be issued upon closing of the transaction. The remaining 339,042 Smart Eye shares will be issued within two years of closing. About $6 million will be paid in cash once the deal closes in June 2021.

Affectiva and Smart Eye were competitors. A meeting at the technology trade show CES in 2020 put the two companies on a path to merge.

“Martin and I realized like, wow, we are on a path to compete with each other — and wouldn’t it be so much better if we joined forces?” Affective co-founder and CEO Dr. Rana el Kaliouby said in an interview Tuesday. “By joining forces, we kind of check all the boxes for what the OEMs are looking for with interior sensing, we leapfrog the competition and we have an opportunity to do this better and faster than we could have done it on our own.”

Boston-based Affectiva brings its emotion-detection software to the deal, which will allow Smart Eye to offer its existing automotive partners a variety of products. Smart Eye helps Affectiva move beyond the development and prototype work and into production contracts. Smart Eye has won 84 production contracts with 13 OEMs, including BMW and GM. Smart Eye, which has offices in Gothenburg, Detroit, Tokyo and Chongqing, China, also has a division that provides research organizations such as NASA with high-fidelity eye tracking systems for human factors research.

Smart Eye founder and CEO Martin Krantz said that European manufacturers building luxury and premium vehicles led the charge for driver monitoring systems.

“We see the same pattern repeating itself now for interior sensing,” Krantz said. “I think a large part of the early contracts will be European premium OEMs such as Mercedes, BMW, Audi, JLR, Porsche.” Krantz added that there are a number of other premium brands it will target in other regions, including Cadillac and Lexus.

The opportunity will initially be in passenger vehicles driven by humans and will eventually expand as greater levels of automated driving enter the market.

Affectiva, which employs 100 people at its offices in Boston and Cairo, also has another business unit that applies its emotio-detection software to media analytics. This division, which will be part of the deal and will operate separately, is profitable, Kaliouby said, noting the software is used by 70% of the world’s largest advertisers to measure and understand emotional responses to media content.

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Getty Images leads $16M investment in Promo.com, a social video template tool

The social video tool Promo.com just raised $16 million in a Series B round led by Getty Images, the company synonymous with stock imagery.

Brands, creators or whoever else might need some quick and dirty video content can search Promo.com for what they need, just like they would use a stock photography service. Getty offers its own library of stock videos as well, but Promo.com provides both the video clips and the tools for non-editors to craft a basic edit with a little bit of customization.

Brands can select an existing professional video clip from a library, plug in their own message and add a logo or custom audio. All that’s left is downloading the customized video and whisking it off to their social channels.

Mizrahi-Tefahot Bank, one of the largest banks in Israel, also participated in the Series B round through debt financing. Promo.com’s existing “strategic partnership” with Getty Images will deepen as part of the deal, giving the former company access to the latter’s expansive existing pool of video clips.

Promo.com video library

Image Credits: Screenshot/Promo.com

Of course, Promo.com isn’t the only show in town. Video creation platform Biteable raised $7 million of its own in December, and similarly allows companies to make bright, bite-sized video content for social. The super streamlined graphic design platform Canva also supports video editing with its own library of stock images. Vimeo offers its own video template service too, known as Vimeo Create, which grew out of the company’s acquisition of the AI-powered video editor Magisto.

 

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Extra Crunch roundup: Lordstown Motors’ woes, how co-CEOs work, Brian Chesky interview

Lordstown Motors released its Q1 earnings yesterday, and the electric vehicle manufacturer is facing a few challenges.

Expenses were higher than expected, it plans to slash production by about 50%, and the company reported zero revenue and a net loss of $125 million. Oh, it also needs more capital.

“But there’s more to the Lordstown mess than merely a single bad quarter,” writes Alex Wilhelm. “Lordstown’s earnings mess and the resulting dissonance with its own predictions are notable on their own, but they also point to what could be shifting sentiment regarding SPAC combinations.”

In light of the company’s lackluster earnings report (and a pending SEC investigation), Alex unpacks the company’s Q1, “but don’t think that we’re only singling out one company; others fit the bill, and more will in time.”

May 27 Clubhouse chat: How to ensure data quality in the era of Big Data

TC unwind chat with Ron Miller and Patrik Liu Tran

Image Credits: TechCrunch

Join TechCrunch reporter Ron Miller and Patrik Liu Tran, co-founder and CEO of automated real-time data validation and quality monitoring platform Validio, on Thursday, May 27 at 9 a.m. PDT/noon EDT for a Clubhouse chat about ensuring data quality in the era of Big Data.

The world produces 2.5 quintillion bytes of data daily, but modern data infrastructure still lacks solutions for monitoring data quality and data validation.

Among other topics, they’ll discuss the build versus buy debate, how to better understand data failures, and why traditional methods for identifying data failures are no longer operational.

Click here to join the conversation.

Thanks very much for reading Extra Crunch; have a great week!

Walter Thompson
Senior Editor, TechCrunch
@yourprotagonist


Full Extra Crunch articles are only available to members.
Use discount code ECFriday to save 20% off a one- or two-year subscription.


How Expensify shed Silicon Valley arrogance to realize its global ambitions

The Expensify origin story

Image Credits: Nigel Sussman

Expensify may be the most ambitious software company ever to mostly abandon the Bay Area as the center of its operations.

The startup’s history is tied to places representative of San Francisco: The founding team worked out of Peet’s Coffee on Mission Street for a few months, then crashed at a penthouse lounge near the 4th and King Caltrain station, followed by a tiny office and then a slightly bigger one in the Flatiron building near Market Street.

Thirteen years later, Expensify still has an office a few blocks away on Kearny Street, but it’s no longer a San Francisco company or even a Silicon Valley firm. The company is truly global with employees across the world — and it did that before COVID-19 made remote working cool.

It makes sense that a company founded by internet pirates would let its workforce live anywhere they please and however they want to. Yet, how does it manage to make it all work well enough to reach $100 million in annual revenue with just a tad more than 100 employees?

As I described in Part 2 of this EC-1, that staffing efficiency is partly due to its culture and who it hires. It’s also because it has attracted top talent from across the world by giving them benefits like the option to work remotely all year as well as paying SF-level salaries even to those not based in the tech hub. It’s also got annual fully paid month-long “workcations” for every employee, their partner and kids.

Brian Chesky describes a faster, nimbler post-pandemic Airbnb

Image Credits: TechCrunch

Managing Editor Jordan Crook interviewed Airbnb co-founder and CEO Brian Chesky to discuss the future of travel and what it was like leading the world’s biggest hospitality startup during a global pandemic.

“Our business initially dropped 80% in eight weeks. I say it’s like driving a car. You can’t go 80 miles an hour, slam on the brakes, and expect nothing really bad to happen.

Now imagine you’re going 80 miles an hour, slam on the brakes, then rebuild the car kind of while still moving, and then try to accelerate into an IPO, all on Zoom.”

Embedded finance will help fill the life insurance coverage gap

Image of a keyboard with one key featuring a family covered by an umbrella to represent life insurance.

Image Credits: alexsl (opens in a new window)/ Getty Images

There’s latent demand for life insurance currently unaddressed by much of the financial services industry, and embedded finance can be the solution.

It’s imperative for companies to consider product lines and partnerships to expand markets, create new revenue streams and provide added value to their customers.

Connecting consumers with products they need through channels they already know and trust is both a massive revenue opportunity and a social good, providing financial resilience to families at a time when they need it most.

Zeta Global’s IPO filing uncovers modest growth, strong adjusted profitability

Zeta Global raised north of $600 million in private capital in the form of both equity financing and debt, making it a unicorn worth understanding.

The gist is that Zeta ingests and crunches lots of data, helping its users market to their customers on a targeted basis throughout their individual buying lifecycles. In simpler terms, Zeta helps companies pitch customers in varied manners depending on their own characteristics.

You can imagine that, as the digital economy has grown, the sort of work Zeta Global supports has only expanded. So, has Zeta itself grown quickly? And does it have an attractive business profile? We want to know.

5 predictions for the future of e-commerce

Image of hands holding credit card and using laptop to represent online shopping/e-commerce.

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In 2016, more than 20 years after Amazon’s founding and 10 years since Shopify launched, it would have been easy to assume e-commerce penetration (the percentage of total retail spend where the goods were bought and sold online) would be over 50%.

But what we found was shocking: The U.S. was only approximately 8% penetrated — only 8% for arguably the most advanced economy in the world!

Despite e-commerce growth skyrocketing over the past year, the reality is the U.S. has still only reached an e-commerce penetration rate of around 17%. During the last 18 months, we’ve closed the gap to South Korea and China’s e-commerce penetration of more than 25%, but there is still much progress to be made.

Here are five key predictions for what this road to further penetration will hold.

Develop a buyer’s guide to educate your startup’s sales team and customers

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Every company wants to be innovative, but innovation comes with its share of difficulties. One key challenge for early-stage companies that are disrupting a particular space or creating a new category is figuring out how to sell a unique product to customers who have never bought such a solution.

This is especially the case when a solution doesn’t have many reference points and its significance may not be obvious.

Some buyers could use a walkthrough of the buying process. If you are building a singular product in a nascent market that necessitates forward-looking customers and want to drastically shorten sales cycles, create a buyer’s guide.

When to walk away from a VC who wants to invest in your startup

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Pay attention to red flags when meeting with VCs: If they cancel late or leave you waiting, it’s a sign, just like being asked generic questions that demonstrate little or no understanding of the proposition. If they critique you or your business, that’s fine (obviously), but make sure you find out what’s behind their assertions to judge how well informed they are.

If you’re going to face these people each month and debate the direction of your business, the least you can expect is a robust argument outlining precisely why you may not have all the right answers.

If you fail to spot the warning signs, you’ll live to regret it. But do your due diligence and work constructively with them and, together, you might actually build a sustainable future.

Deep Science: Robots, meet world

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This column aims to collect some of the most relevant recent discoveries and papers — particularly in, but not limited to, artificial intelligence — and explain why they matter.

In this edition, we have a lot of items concerned with the interface between AI or robotics and the real world. Of course, most applications of this type of technology have real-world applications, but specifically, this research is about the inevitable difficulties that occur due to limitations on either side of the real-virtual divide.

2 CEOs are better than 1

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Netflix has two CEOs: Co-founder Reed Hastings oversees the streaming side of the company, while Ted Sarandos guides Netflix’s content.

Warby Parker has co-CEOs as well — its co-founders went to college together. Other companies like the tech giant Oracle and luggage maker Away have shifted from having co-CEOs in recent years, sparking a wave of headlines suggesting that the model is broken.

While there isn’t a lot of research on companies with multiple CEOs, the data is more promising than the headlines would suggest. One study on public companies with co-CEOs revealed that the average tenure for co-CEOs, about 4.5 years, was comparable to solitary CEOs, “suggesting that this arrangement is more stable than previously believed.”

Furthermore, it’s impossible to be in two places at once or clone yourself. With co-CEOs, you can effectively do just that.

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What Vimeo’s growth, profits and value tell us about the online video market

The spinout of video platform Vimeo from IAC completed today, with the smaller company now trading as an independent entity under the ticker symbol VMEO.

If you missed the news that the internet conglomerate was spinning out the video service, don’t feel bad; it slipped past many radars. But with the company now trading, with our access to its historical results, and with our minds still enthralled by YouTube’s recent financial performance for Alphabet, it’s worth taking a moment to digest the company’s health.

Let’s answer a few questions: How quickly is Vimeo growing, how profitable is its business, and what can its spinout tell us about the larger video market? Recall that Kaltura, another video-powering company, recently put its IPO back into the pipeline after a small delay during what felt like a snap-freeze of the public markets toward the start of the second quarter.

So the Vimeo debut could impact a possible forthcoming unicorn IPO. With that in mind, let’s dig into the numbers.

Growth

From Q1 2020 to Q1 2021, Vimeo’s revenues expanded from $57 million to $89.4 million, a gain of around 57%. That’s a solid pace of expansion, but not a surprising one considering how much digital video the world consumed during the COVID-19 pandemic, a fact that could have bolstered the company’s recent performance.

Over the same time frame, Vimeo’s gross profit grew from $38.6 million to $64.5 million, a gain of around 67%. As you can infer from faster-rising gross profit than revenue, Vimeo’s gross margins improved during Q1 2021 compared to the first quarter of 2020, from 68% to 72%.

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Call it a comeback: Turntable.fm raises $7.5M

Earlier this year, Turntable.fm’s founder Billy Chasen dusted off the old site and resurrected it for the pandemic age. I know I wasn’t the only one feeling a wistful pang of nostalgia for the service during the long, dull days of sheltering in place. And while March 2020 would have been the best time for a relaunch, March 2021 was pretty good, too.

Today Chasen announced that the service has received a nice little slice of VC backing to help the service (which has thus far been invite/password only) take the next step. Andreessen Horowitz led the $7.5 million round a decade after the site’s original launch. Funding had thus far been limited to fans through services like Patreon and Venmo. He notes that he will be turning off the service’s Patreon.

Chasen is staying mum as far as where the funding will go, stating, “And now with the new fundraising, we can continue to innovate and truly explore the cross section of social + music. I have a lot of ideas for the space and I’m excited to start building them.”

Though, a blog post does note that the company is hiring engineers and designers. Understandable, though as someone who’s been enjoying the site these last few months, I’m actually pretty surprised at how fresh the whole thing feels.

The team found a clever loophole around music rights in the form of YouTube videos, but perhaps a future version of the service will involve more direct music licensing or ties to popular apps like Spotify. A mobile app would be nice, if I’m just spitballing here.

Turntable.fm initially shut down back in 2013, stating at the time, “It was a tough decision to make because we love this community so much, but the cost of running a music service has been too expensive and we can’t outpace it with our efforts to monetize it and cut costs.” The service added that it was focusing on a live events platform instead.

Notably, Turntable.fm is not the only Turntable service looking to relaunch in 2021. There’s also Turntable.org (confusingly located at TT.fm), which is seeking fan funding, as well as looking toward a subscription fee. It announced that it had raised $500,000 in March and was aiming for an April launch for a mobile and desktop version. The site currently reads, “We’re building a new version just as much fun as the original.”

The two Turntables are not affiliated.

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